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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1097260Generated: November 1, 2026

ethyl 5-fluoro-1H-indole-2-carboxylate → ethyl 5-fluoro-1-[2-[(5-methylpyridin-2-yl)oxy]-ethyl]-1H-indole-2-carboxylate

https://huagongshe.com/reaction/1097260

Reaction equation

Participants

RoleNameHCIDCharge
Reactantethyl 5-fluoro-1H-indole-2-carboxylateHCID 2727899—
Reactant2-[(5-Methylpyridin-2-yl)oxy]ethanolHCID 20795169—
Productethyl 5-fluoro-1-[2-[(5-methylpyridin-2-yl)oxy]-ethyl]-1H-indole-2-carboxylateHCID 66811445—

Reaction Steps

The ethyl 5-fluoro-1-[2-[(5-methylpyridin-2-yl)oxy]-ethyl]-1H-indole-2-carboxylate intermediate is prepared in a manner similar to the method described in Example 18.1, from ethyl 5-fluoro-1H-indole-2-carboxylate and 2-(5-methylpyridin-2-yloxy)ethanol prepared in the preceding step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08143248B2
Source datasetuspto-grants-2012_03
ORD IDord-095b3475a50746a1ade63bf4a562cf69
Source noteuspto-grants-2012_03