HCID 24765764, compound → 5-Ethyl-1-propyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione

HRID 1097273Notes

Reaction equation

HRID 1097273 reaction equation
CN1C(=O)C(C)(N2[C:17](=[O:18])[C:16]3[C:11](=[C:12]([F:22])[C:13]([F:21])=[C:14]([F:20])[C:15]=3[F:19])[C:10]2=[O:23])C(=O)NC1=O.Cl.[NH2:28][C:29]1([CH2:41][CH3:42])[C:34](=[O:35])[N:33]([CH2:36][CH2:37][CH3:38])[C:32](=[O:39])[NH:31][C:30]1=[O:40]>>[CH2:41]([C:29]1([N:28]2[C:10](=[O:23])[C:11]3[C:16](=[C:15]([F:19])[C:14]([F:20])=[C:13]([F:21])[C:12]=3[F:22])[C:17]2=[O:18])[C:34](=[O:35])[N:33]([CH2:36][CH2:37][CH3:38])[C:32](=[O:39])[NH:31][C:30]1=[O:40])[CH3:42]

Participants

3

Reactant 2

HCID 24765764HCID 24765764, compoundHCID 66811200HCID 66811200, compound

Product 1

HCID 247656675-Ethyl-1-propyl-5-(4,5,6,7-tetrafluoro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione

Procedure

Compound 19e was synthesized in the same manner as described for 19a from 5-amino-5-ethyl-1-propylbarbituric acid hydrochloride (0.38 g, 1.50 mmol). The crude product was recrystallized from EtOH (70%) to give 5-ethyl-1-propyl-5-(tetrafluorophthalimido)-barbituric acid (19e) as white crystals.

Workup

  1. customCompound 19e was synthesized in the same manner
  2. customThe crude product was recrystallized from EtOH (70%)

Sources & evidence

ORD record
ord-12774bce4aa8473bb928f028b110f61d
Source dataset
uspto-grants-2012_03
Patent number
US08143252B2

Reaction notes

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