Lithium Hydroxide → HCID 59443498, compound

Participants

Reaction Steps

3-[3-(2-Phenyl-pyridin-4-yl)-imidazo[1,2-b]pyridazin-7-yl]-benzoic acid ethyl ester (1 eq, 0.119 mmol, 50 mg) (Ex. 42) is dissolved in THF/H2O/MeOH (0.5/0.25/0.25 ml) and LiOH (20 eq, 2.38 mmol, 57 mg) is then added and the reaction is stirred at room temperature for 1 h. The reaction mixture is then diluted with MeOH and HCl (1M) is added. The precipitate is filtered and dried to afford 3-[3-(2-Phenyl-pyridin-4-yl)-imidazo[1,2-b]pyridazin-7-yl]-benzoic acid as a yellow solid which did not require further purification; [M+H]+=393

Provenance & Evidence