Lithium Hydroxide → HCID 59443498, compound

HRID 1097307Notes

Reaction equation

HRID 1097307 reaction equation
C([O:3][C:4](=[O:32])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH:16]=[N:15][N:14]3[C:17]([C:20]4[CH:25]=[CH:24][N:23]=[C:22]([C:26]5[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=5)[CH:21]=4)=[CH:18][N:19]=[C:13]3[CH:12]=2)[CH:6]=1)C.[Li+].[OH-]>C1COCC1.O.CO.CO.Cl>[C:26]1([C:22]2[CH:21]=[C:20]([C:17]3[N:14]4[N:15]=[CH:16][C:11]([C:7]5[CH:6]=[C:5]([CH:10]=[CH:9][CH:8]=5)[C:4]([OH:32])=[O:3])=[CH:12][C:13]4=[N:19][CH:18]=3)[CH:25]=[CH:24][N:23]=2)[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

6

Reactant 2

HCID 3939Lithium HydroxideHCID 25176545HCID 25176545, compound

Product 1

HCID 59443498HCID 59443498, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 21892291Methanol tetrahydrofuran waterSolvent

Procedure

3-[3-(2-Phenyl-pyridin-4-yl)-imidazo[1,2-b]pyridazin-7-yl]-benzoic acid ethyl ester (1 eq, 0.119 mmol, 50 mg) (Ex. 42) is dissolved in THF/H2O/MeOH (0.5/0.25/0.25 ml) and LiOH (20 eq, 2.38 mmol, 57 mg) is then added and the reaction is stirred at room temperature for 1 h. The reaction mixture is then diluted with MeOH and HCl (1M) is added. The precipitate is filtered and dried to afford 3-[3-(2-Phenyl-pyridin-4-yl)-imidazo[1,2-b]pyridazin-7-yl]-benzoic acid as a yellow solid which did not require further purification; [M+H]+=393

Workup

  1. additionis added
  2. filtrationThe precipitate is filtered
  3. customdried

Sources & evidence

ORD record
ord-9472b84b1d494e1aaafc5f75f0e5fcfb
Source dataset
uspto-grants-2012_03
Patent number
US08143253B2

Reaction notes

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