Bromoform → 2-[[2-Bromo-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-2-methyl-1-propanol

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from example 1 step d) (0.1 g) in bromoform (5 ml) was added isoamylnitrite (0.13 ml) and the mixture heated at 60° C. for 10 mins. The mixture was evaporated to dryness and purified (SiO2, ethyl acetate:dichloromethane 1:9 as eluant) to give the subtitle compound as a colourless solid (0.043 g).

Provenance & Evidence