2-(2-chloro-4-formylphenoxy)acetamide → HCID 22671343, compound

HRID 1097342Notes

Reaction equation

HRID 1097342 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([CH:13]=[O:14])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([NH2:8])=[O:7].[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:12]=[C:11]([CH2:13][OH:14])[CH:10]=[CH:9][C:3]=1[O:4][CH2:5][C:6]([NH2:8])=[O:7]

Participants

4

Reactant 2

HCID 9777592-(2-chloro-4-formylphenoxy)acetamideHCID 4311764Sodium borohydride

Product 1

HCID 22671343HCID 22671343, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of the product from example 15 step a) (4.4 g) in ethanol (500 ml) was added sodium borohydride (1.56 g) and the mixture allowed to stir for 1 hour. Acidified with glacial acetic acid, evaporated to dryness and extracted into ethyl acetate, washed with water to give the subtitle compound (4.3 g).

Workup

  1. customAcidified with glacial acetic acid, evaporated to dryness
  2. extractionextracted into ethyl acetate
  3. washwashed with water

Sources & evidence

ORD record
ord-6e7fa8c9efec4c85a2549025e7a271dc
Source dataset
uspto-grants-2012_03
Patent number
US08143261B2

Reaction notes

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