Sodium Hydroxide → HCID 135555956, compound

HRID 1097348Notes

Reaction equation

HRID 1097348 reaction equation
O.[NH2:2][C:3]1[CH:8]=[C:7]([OH:9])[N:6]=[C:5]([SH:10])[N:4]=1.[OH-].[Na+].O.Cl.Cl[CH2:16][C:17]1[N:18]=[C:19]([CH3:22])[S:20][CH:21]=1>CN(C=O)C>[NH2:2][C:3]1[N:4]=[C:5]([S:10][CH2:16][C:17]2[N:18]=[C:19]([CH3:22])[S:20][CH:21]=2)[NH:6][C:7](=[O:9])[CH:8]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 22671367HCID 22671367, compoundHCID 178507962HCID 178507962, compound

Product 1

HCID 135555956HCID 135555956, compoundYield 96.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Amino-6-hydroxy-2-mercaptopyrimidine hydrate (16.1 g) and powdered sodium hydroxide, (8.0 g) was stirred in dry DMF (100 ml) for 20 mins. 4-Chloromethyl-2-methylthiazole hydrochloride monohydrate (20 g) was added portionwise and the resulting suspension stirred 18 hrs. The mixture was poured onto water and the solid collected, washed with water and dried to afford the sub-title compound (24.3 g)

Workup

  1. additionThe mixture was poured onto water
  2. customthe solid collected
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-663f61e1d7bb4b48b107a33af1694bc7
Source dataset
uspto-grants-2012_03
Patent number
US08143261B2

Reaction notes

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