反应详情

温度

60 °C

The product of example 4 step (b) (8.0 g) was suspended in bromoform (200 ml) followed by addition of tert-butyl nitrite (8 ml) and the whole heated at 60° C. for 30 minutes. The solvents were removed by reduced pressure and the residue purified by column chromatography (silica—1:1 dichloromethane/isohexane) to give a yellow solid (5.6 g).

1. customThe solvents were removed by reduced pressure
2. customthe residue purified by column chromatography (silica—1:1 dichloromethane/isohexane)