反应详情

The product of example 31 step a) (5.6 g) was suspended in methanol (150 ml) and potassium hydroxide powder (0.77 g) added. The whole was stirred at room temperature for 2 hours. The mixture was adjusted to pH 7 with a few drops of concentrated hydrochloric acid before it was evaporated to dryness. Purified by column chromatography (silica—3:2 to 1:1 isohexane/dichloromethane) to give white solid (2.0 g).

1. customwas evaporated to dryness
2. customPurified by column chromatography (silica—3:2 to 1:1 isohexane/dichloromethane)