Ammonium Chloride → HCID 178461804, compound

HRID 1097364Notes

Reaction equation

HRID 1097364 reaction equation
[Na].[NH2:2][C:3]1[S:4][C:5]2[C:10]([NH:11][C@H:12]([CH3:15])[CH2:13][OH:14])=[N:9][C:8]([S:16]CC3C=CC=CC=3)=[N:7][C:6]=2[N:24]=1.[Cl-].[NH4+]>N>[NH2:2][C:3]1[S:4][C:5]2[C:10]([NH:11][C@H:12]([CH3:15])[CH2:13][OH:14])=[N:9][C:8]([SH:16])=[N:7][C:6]=2[N:24]=1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 11857680(2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

Product 1

HCID 178461804HCID 178461804, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

Sodium metal was added portionwise to a solution of the product of example 32 step a) (5.0 g) in ammonia (150 ml) until a blue colouration persisted. Ammonium chloride was then added and the solvent allowed to evaporate. The residue was dissolved in H2O (200 ml) and filtered before neutralising with 2M HCl solution. The grey precipitate was filtered, washed with H2O (200 ml) and dried in vacuo for 48 h to yield the subtitle compound as a brown solid (3.0 g).

Workup

  1. customto evaporate
  2. dissolutionThe residue was dissolved in H2O (200 ml)
  3. filtrationfiltered
  4. filtrationThe grey precipitate was filtered
  5. washwashed with H2O (200 ml)
  6. customdried in vacuo for 48 h

Sources & evidence

ORD record
ord-bd6e6c2172dc4270a574eef69b9b5a8d
Source dataset
uspto-grants-2012_03
Patent number
US08143261B2

Reaction notes

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