反应详情

2-fluorobenzylbromide (0.369 g) was added portionwise to a solution of the product of example 32 step b) (0.5 g) and diisopropylethylamine (0.26 g) in DMSO/N-methylpyrrolidinone (4 ml/0.5 ml) at 50° C. and stirring maintained for 1 h. The mixture was partitioned between H2O (200 ml) and EtOAc (120 ml). The organics were recovered and washed further with H2O (200 ml), dried over MgSO4 and concentrated onto silica gel. The subtitle compound was purified by flash chromatography using DCM then EtOAc as eluents to yield a white solid (245 mg, 35%).

1. temperaturemaintained for 1 h
2. customThe mixture was partitioned between H2O (200 ml) and EtOAc (120 ml)
3. customThe organics were recovered
4. washwashed further with H2O (200 ml)
5. dry with materialdried over MgSO4
6. concentrationconcentrated onto silica gel
7. customThe subtitle compound was purified by flash chromatography