HCID 66811298, compound → HCID 66811315, compound

HRID 1097408Notes

Reaction equation

HRID 1097408 reaction equation
[CH:1]1[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([CH2:12][CH:13]=[CH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:5]=2[CH:4]=[CH:3][CH:2]=1>C(OCC)(=O)C.[Pd]>[CH:1]1[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 66811298HCID 66811298, compound

Product 1

HCID 66811315HCID 66811315, compoundYield 97.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of ethyl 4-(6,7,8,9-tetrahydro-5H-5-benzocycloheptenyl)-2-butenoate (0.544 g) in ethyl acetate (10 ml) was added with 10% palladium/carbon (0.054 g), and the mixture was stirred for 3 hours under a hydrogen flow. The reaction mixture was filtered through Celite, and then the solvent of the filtrate was concentrated under reduced pressure to obtain the title compound (0.534 g, yield: 97%).

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe solvent of the filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-1a130a1cf8a4432885ff965f9129fba0
Source dataset
uspto-grants-2012_03
Patent number
US08143260B2

Reaction notes

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