8-Nitro-8-phenyl-hexahydro-indolizin-5-one → 8-Amino-8-phenyl-hexahydro-indolizin-5-one

HRID 1097626노트

반응식

HRID 1097626 반응식
[N+:1]([C:4]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:12]2[N:8]([CH2:9][CH2:10][CH2:11]2)[C:7](=[O:13])[CH2:6][CH2:5]1)([O-])=O>C1COCC1.[Ni]>[NH2:1][C:4]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:12]2[N:8]([CH2:9][CH2:10][CH2:11]2)[C:7](=[O:13])[CH2:6][CH2:5]1

참가 물질

4

반응물 1

HCID 585679098-Nitro-8-phenyl-hexahydro-indolizin-5-one

생성물 1

HCID 585679118-Amino-8-phenyl-hexahydro-indolizin-5-one

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 60 mg (0.231 mmol) (8R,S; 8aS,R)-8-nitro-8-phenyl-hexahydro-indolizin-5-one in 1 ml THF were added 100 ul of Raney Nickel (55% in water). The mixture was stirred at room temperature under a hydrogen atmosphere for 90 hours. The apparatus was purged with argon. The catalyst was filtered (under argon), washed with THF and the filtrate was concentrated in vacuo to provide 38 mg (y: 72%) of title compound as a colorless oil. (M+H+: 231.3).

후처리

  1. customThe apparatus was purged with argon
  2. filtrationThe catalyst was filtered (under argon)
  3. washwashed with THF
  4. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-8bda674745534479b234310be26c85e4
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143273B2

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