反应详情

To a solution of 60 mg (0.231 mmol) (8R,S; 8aS,R)-8-nitro-8-phenyl-hexahydro-indolizin-5-one in 1 ml THF were added 100 ul of Raney Nickel (55% in water). The mixture was stirred at room temperature under a hydrogen atmosphere for 90 hours. The apparatus was purged with argon. The catalyst was filtered (under argon), washed with THF and the filtrate was concentrated in vacuo to provide 38 mg (y: 72%) of title compound as a colorless oil. (M+H+: 231.3).

1. customThe apparatus was purged with argon
2. filtrationThe catalyst was filtered (under argon)
3. washwashed with THF
4. concentrationthe filtrate was concentrated in vacuo