反应详情

To a solution of 230 mg (0.688 mmol) 2-(3-nitro-3-phenyl-propyl)-pyrrolidine-1-carboxylic acid tert-butyl ester in 3.5 ml methanol were added 860 ul (0.3.44 mmol) of a 4M HCl solution in dioxane. The mixture was stirred at room temperature for 17 hours. The solvent was removed in vacuo. The residue was dissolved in water. The mixture was basified with a saturated sodium bicarbonate solution and extracted 6 times with dichloromethane. The combined extracts were dried over sodium sulfate, filtered and concentrated in vacuo to provide 96 mg (y: 59.6%) of the title compound as a white solid. MS (m/e): 235.2 (M+H+).

1. customThe solvent was removed in vacuo
2. dissolutionThe residue was dissolved in water
3. extractionextracted 6 times with dichloromethane
4. dry with materialThe combined extracts were dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo