HCID 58567903, compound → 6-Phenyloctahydroindolizin-6-amine

HRID 1097630Notes

Reaction equation

HRID 1097630 reaction equation
[N+:1]([C:4]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][CH:10]2[N:6]([CH2:7][CH2:8][CH2:9]2)[CH2:5]1)([O-])=O>C1COCC1.[Ni]>[C:13]1([C:4]2([NH2:1])[CH2:12][CH2:11][CH:10]3[N:6]([CH2:7][CH2:8][CH2:9]3)[CH2:5]2)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 1

HCID 58567903HCID 58567903, compound

Product 1

HCID 585679026-Phenyloctahydroindolizin-6-amine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 62 mg (0.252 mmol) 6-nitro-6-phenyl-octahydro-indolizine in 2.0 ml THF was added 150 ul Raney Nickel (50% in water). The mixture was stirred under a hydrogen atmosphere for 2 hours. The apparatus was purged with argon. The catalyst was filtered, washed with THF and the filtrate was concentrated in vacuo to provide 57 mg (y: 100%) of the title compound as a colorless oil. MS (m/e): 217.4 (M+H+).

Workup

  1. customThe apparatus was purged with argon
  2. filtrationThe catalyst was filtered
  3. washwashed with THF
  4. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-311aa101d3454e23abad17800927e362
Source dataset
uspto-grants-2012_03
Patent number
US08143273B2

Reaction notes

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