反应详情

温度

60 °C

A solution of 8-chloro-7-(2-propen-1-yl)-3-(4,4,4-trifluorobutyl)-3,7-dihydro-1H-purine-2,6-dione (1.0 g, 3.0 mmol) in DMF (15 ml) was treated with caesium carbonate (1.16 g, 3.6 mmol) and 3-bromo-1-propanol (0.3 ml, 3.3 mmol). The mixture was heated at 60° C. for 4 h and then cooled and evaporated. The residue was partitioned between EtOAc (50 ml) and water (50 ml). The organic phase was dried (MgSO4), filtered and evaporated. The product was purified by flash chromatography using a gradient elution from cyclohexane to EtOAc. Product-containing fractions were combined and evaporated to give the title compound as a colourless oil (0.82 g, 75%).

1. temperaturecooled
2. customevaporated
3. customThe residue was partitioned between EtOAc (50 ml) and water (50 ml)
4. dry with materialThe organic phase was dried (MgSO4)
5. filtrationfiltered
6. customevaporated
7. customThe product was purified by flash chromatography
8. washa gradient elution from cyclohexane to EtOAc
9. customevaporated