2-Thiophenecarboxylic acid → 8-Chloro-3-pentyl-1-{4-[5-(2-thienyl)-1,2,4-oxadiazol-3-yl]butyl}-3,7-dihydro-1H-purine-2,6-dione

Participants

Reaction Conditions

Reaction Steps

2-Thiophenecarboxylic acid (14 mg, 0.11 mmol) was dissolved in NMP (0.9 ml) and treated with CDl (18 mg, 0.11 mmol). After 1 h, (1Z)-5-(8-chloro-2,6-dioxo-3-pentyl-2,3,6,7-tetrahydro-1H-purin-1-yl)-N-hydroxypentanimidamide (50 mg, 0.13 mmol) was added and the mixture heated in the microwave at 150° C. for 15 min. The solution was directly purified by MDAP to obtain the title compound which was then freeze dried from 1,4-dioxane to give the title compound as a white solid (19 mg, 31%).

Provenance & Evidence