反应详情

温度

0 °C

To N-hydroxybenzenecarboximidoyl chloride (622 mg, 4 mmol) in dry DCM (6 ml) was added 5-hexyn-1-ol (431 mg, 4.4 mmol). The mixture was cooled to 0° C. under nitrogen as triethylamine (0.612 ml, 4.4 mmol) was added dropwise over 10 min. Stirred for a further 20 min at 0° C. then at room temperature overnight. The mixture was washed with water and the organic phase evaporated. The product was purified by silica SPE (20 g) eluting with EtOAc-cyclohexane (1:2, then 3:1) to give a white waxy solid (443 mg).

1. additionwas added dropwise over 10 min
2. customat room temperature
3. customovernight
4. washThe mixture was washed with water
5. customthe organic phase evaporated
6. customThe product was purified by silica SPE (20 g)
7. washeluting with EtOAc-cyclohexane (1:2