3-[3-(Phenylmethyl)-5-isoxazolyl]-1-propanol → 3-Butyl-8-chloro-1-{3-[3-(phenylmethyl)-5-isoxazolyl]propyl}-3,7-dihydro-1H-purine-2,6-dione

HRID 1097720Notes

Reaction equation

HRID 1097720 reaction equation
[CH2:1]([N:5]1[C:13]2[N:12]=[C:11]([Cl:14])[NH:10][C:9]=2[C:8](=[O:15])[N:7]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]2ON=[C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:21]=2)[C:6]1=[O:31])[CH2:2][CH2:3][CH3:4].C(N1C2N=C(Cl)N(CC=C)C=2C(=O)NC1=O)CCC.C1(CC2C=C(CCCO)[O:60][N:59]=2)C=CC=CC=1>>[CH2:1]([N:5]1[C:13]2[N:12]=[C:11]([Cl:14])[NH:10][C:9]=2[C:8](=[O:15])[N:7]([CH2:16][CH2:17][CH2:18][C:19]2[O:60][N:59]=[C:21]([CH2:22][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH:20]=2)[C:6]1=[O:31])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 584780973-[3-(Phenylmethyl)-5-isoxazolyl]-1-propanolHCID 592995823-butyl-8-chloro-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dioneHCID 593954633-Butyl-8-chloro-1-[4-(3-phenyl-5-isoxazolyl)butyl]-3,7-dihydro-1H-purine-2,6-dione

Product 1

HCID 593957563-Butyl-8-chloro-1-{3-[3-(phenylmethyl)-5-isoxazolyl]propyl}-3,7-dihydro-1H-purine-2,6-dione

Procedure

Prepared analogously to 3-butyl-8-chloro-1-[4-(3-phenyl-5-isoxazolyl)butyl]-3,7-dihydro-1H-purine-2,6-dione (Example 213) using half the molar quantities, starting from 3-butyl-8-chloro-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione (50 mg, 0.177 mmol) and 3-[3-(phenylmethyl)-5-isoxazolyl]-1-propanol (38.4 mg, 0.177 mmol). Yield 24.2 mg,

Sources & evidence

ORD record
ord-bef2c7f79d28438e8ec7a651c21bdf8e
Source dataset
uspto-grants-2012_03
Patent number
US08143264B2

Reaction notes

Loading…