HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[3-(Phenylmethyl)-5-isoxazolyl]-1-propanol → 3-Butyl-8-chloro-1-{3-[3-(phenylmethyl)-5-isoxazolyl]propyl}-3,7-dihydro-1H-purine-2,6-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[3-(Phenylmethyl)-5-isoxazolyl]-1-propanol | HCID 58478097 | — |
| Reactant | 3-butyl-8-chloro-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione | HCID 59299582 | — |
| Reactant | 3-Butyl-8-chloro-1-[4-(3-phenyl-5-isoxazolyl)butyl]-3,7-dihydro-1H-purine-2,6-dione | HCID 59395463 | — |
| Product | 3-Butyl-8-chloro-1-{3-[3-(phenylmethyl)-5-isoxazolyl]propyl}-3,7-dihydro-1H-purine-2,6-dione | HCID 59395756 | — |
Reaction Steps
Prepared analogously to 3-butyl-8-chloro-1-[4-(3-phenyl-5-isoxazolyl)butyl]-3,7-dihydro-1H-purine-2,6-dione (Example 213) using half the molar quantities, starting from 3-butyl-8-chloro-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione (50 mg, 0.177 mmol) and 3-[3-(phenylmethyl)-5-isoxazolyl]-1-propanol (38.4 mg, 0.177 mmol). Yield 24.2 mg,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143264B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-bef2c7f79d28438e8ec7a651c21bdf8e |
| Source note | uspto-grants-2012_03 |