Potassium Carbonate → HCID 59395380, compound

HRID 1097725Notes

Reaction equation

HRID 1097725 reaction equation
[Cl:1][C:2]1[N:10]([CH2:11][CH:12]=[CH2:13])[C:9]2[C:8](=[O:14])[N:7]([CH2:15][CH:16](O)[CH2:17][CH2:18]CCC3C=CC=CC=3)[C:6](=[O:28])[N:5]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:4]=2[N:3]=1.BrCCCC[N:39]1[CH2:43][CH2:42][CH:41]([CH2:44][C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)[C:40]1=[O:51].C(=O)([O-])[O-].[K+].[K+]>>[Cl:1][C:2]1[N:10]([CH2:11][CH:12]=[CH2:13])[C:9]2[C:8](=[O:14])[N:7]([CH2:15][CH2:16][CH2:17][CH2:18][N:39]3[CH2:43][CH2:42][CH:41]([CH2:44][C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=4)[C:40]3=[O:51])[C:6](=[O:28])[N:5]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:4]=2[N:3]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 59395622HCID 59395622, compoundHCID 59405189HCID 59405189, compound

Product 1

HCID 59395380HCID 59395380, compoundYield 86%

Conditions

Temperature
50 °C

Procedure

Prepared as with 8-chloro-1-(2-hydroxy-6-phenylhexyl)-3-pentyl-7-(2-propen-1-yl)-3,7-dihydro-1H-purine-2,6-dione using 1-(4-bromobutyl)-3-(phenylmethyl)-2-pyrrolidinone as the alkylating agent, potassium carbonate as base and heating at 50° C. for 18 h. Yield 86%.

Sources & evidence

ORD record
ord-f88c6abe7d4b4fb6a222f8ec8401b75c
Source dataset
uspto-grants-2012_03
Patent number
US08143264B2

Reaction notes

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