反应详情

温度

100 °C

3-amino-4-pyrazole carbonitrile (400 mg, 3.7 mmol) and dihydroxyfumarate (978 mg, 5.5 mmol) were dissolved in glacial acetic acid (5 mL) and the mixture was heated to 100° C. After 2 d, the reaction was complete by HPLC analysis and was cooled to room temperature. Ethyl acetate (10 mL) was added to initiate precipitation of product and the resulting precipitate was collected by filtration. The product was isolated in 62% yield (534 mg).

1. temperaturewas cooled to room temperature
2. customprecipitation of product
3. filtrationthe resulting precipitate was collected by filtration
4. customThe product was isolated in 62% yield (534 mg)