Trifluoroacetic acid → HCID 58100971, compound

HRID 1097758Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]2[N:18]([CH2:19][CH2:20][N:21]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)[C:17]3[CH:34]=[CH:35][CH:36]=[CH:37][C:16]=3[N:8]2[C:9](=[O:15])[C:10]=1[O:11][C:12](=[O:14])[CH3:13])=[O:4].FC(F)(F)C(O)=O>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[C:7]2[N:18]([CH2:19][CH2:20][N:21]3[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]3)[C:17]3[CH:34]=[CH:35][CH:36]=[CH:37][C:16]=3[N:8]2[C:9](=[O:15])[C:10]=1[O:11][C:12](=[O:14])[CH3:13])=[O:4]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 58101071HCID 58101071, compound

Product 1

HCID 58100971HCID 58100971, compound

Procedure

3-Acetoxy-10-[2-(4-tert-butoxycarbonyl-piperazin-1-yl)-ethyl]-4-oxo-4,10-dihydro-benzo[4,5]imidazo[1,2-a]pyrimidine-2-carboxylic acid methyl ester (33 mg, 0.064 mmol) was treated with trifluoroacetic acid (0.20 mL) and stirred for one hour at room temperature. After this time, the mixture was concentrated and the crude residue was the desired product (27 mg, 100%).

Workup

concentrationAfter this time, the mixture was concentrated

Sources & evidence

ORD record: ord-f28acb07cf3a4663a0986eeaf942bbf2
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08143268B2

Reaction notes

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