反应详情

A mixture of 3-Hydroxy-2,2-dimethyl-3-(2-nitro-phenyl)-propionic acid methyl ester (800 mg), Palladium on carbon (10%, 80 mg) in 5 mL of MeOH under 1 atm hydrogen gas is stirred at room temperature for 4 h. The mixture is filtered through a pad of celite and washed with MeOH. The combined solution is concentrated and the residue is purified by flash column and gives 250 mg colorless solid.

1. filtrationThe mixture is filtered through a pad of celite
2. washwashed with MeOH
3. concentrationThe combined solution is concentrated
4. customthe residue is purified by flash column