HCID 11448149, compound → 4-Hydroxy-3,3-dimethyl-3,4-dihydro-1H-quinolin-2-one

Participants

Reaction Steps

A mixture of 3-Hydroxy-2,2-dimethyl-3-(2-nitro-phenyl)-propionic acid methyl ester (800 mg), Palladium on carbon (10%, 80 mg) in 5 mL of MeOH under 1 atm hydrogen gas is stirred at room temperature for 4 h. The mixture is filtered through a pad of celite and washed with MeOH. The combined solution is concentrated and the residue is purified by flash column and gives 250 mg colorless solid.

Provenance & Evidence