HCID 66811027, compound → (2-Cyclohexylphenyl)carbamic Acid Piperidin-4-yl Ester

HRID 1097825Notes

Reaction equation

HRID 1097825 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15](=[O:29])[NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][C:15](=[O:29])[NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)[CH2:12][CH2:13]1

Participants

4

Reactant 1

HCID 66811027HCID 66811027, compound

Product 1

HCID 66810986(2-Cyclohexylphenyl)carbamic Acid Piperidin-4-yl Ester

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A stirred solution of the product of step (b) (3.22 g, 8.00 mmol) in 4 M hydrochloric acid in dioxane (40 mL) was heated at 50° C. After 8 h, the reaction mixture was allowed to cool to room temperature and the solvent was removed under reduced pressure to give the title compound. MS m/z: [M+H+] calcd for C18H26N2O2 303.20; found 303.5. 1H NMR (CD3OD, δ): 7.2 (m, 4H), 4.95 (m, 1H), 4.85 (s, 1H), 3.3 (br m, 3H), 2.8 (br m, 1H), 2.2 (br m, 2H), 2.0 (br m, 2H), 1.8 (br m, 5H), 1.4 (br m, 5H).

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-d637cdd0307f40df8371ad2b82df93c2
Source dataset
uspto-grants-2012_03
Patent number
US08143277B2

Reaction notes

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