Isopropanol → HCID 25253664, compound

HRID 1097865Notes

Reaction equation

HRID 1097865 reaction equation
C(O)(C)C.[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[CH:13]([CH3:27])[C:14]([C:20]1[CH:25]=[N:24][CH:23]=[C:22]([CH3:26])[N:21]=1)([OH:19])[C:15]([F:18])([F:17])[F:16]>CCCCCCC>[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[C@@H:13]([CH3:27])[C@:14]([C:20]1[CH:25]=[N:24][CH:23]=[C:22]([CH3:26])[N:21]=1)([OH:19])[C:15]([F:18])([F:16])[F:17]

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 25253518HCID 25253518, compound

Product 1

HCID 25253664HCID 25253664, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

These compounds were obtained by preparative HPLC (Column: Chiralpack AD; solvent: 1% isopropanol in heptane) from racemic 3-(2,4-dichloro-phenyl)-1,1,1-trifluoro-2-(6-methyl-pyrazin-2-yl)-butan-2-ol (Example 39).

Sources & evidence

ORD record
ord-bdee74ff9c1449d2850b13132bdf59dc
Source dataset
uspto-grants-2012_03
Patent number
US08143280B2

Reaction notes

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