Isopropanol → HCID 57421230, compound

HRID 1097872Notes

Reaction equation

HRID 1097872 reaction equation
C(O)(C)C.[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[CH:13]([CH3:30])[C:14]([C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][CH:29]=1)[N:26]=[CH:25][CH:24]=[CH:23]2)([OH:19])[C:15]([F:18])([F:17])[F:16]>CCCCCCC>[Cl:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[C@@H:13]([CH3:30])[C@:14]([C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][CH:29]=1)[N:26]=[CH:25][CH:24]=[CH:23]2)([OH:19])[C:15]([F:18])([F:17])[F:16]

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 25253826HCID 25253826, compound

Product 1

HCID 57421230HCID 57421230, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

These materials were obtained by preparative HPLC (Column: Chiralpack AD; solvent: 1% isopropanol in heptane) from racemic 3-(2,4-dichloro-phenyl)-1,1,1-trifluoro-2-quinolin-6-yl-butan-2-ol (example 52).

Sources & evidence

ORD record
ord-383e6a41f21147a297f516bb492698da
Source dataset
uspto-grants-2012_03
Patent number
US08143280B2

Reaction notes

Loading…