5-[2-(2,4-Dichloro-phenyl)-acryloyl]-1H-pyridin-2-one → 5-[2-(2,4-Dichloro-phenyl)-propionyl]-1H-pyridin-2-one

HRID 1097967Notes

Reaction equation

HRID 1097967 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[CH2:19])[C:10]([C:12]1[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=1)=[O:11]>CCOC(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:19])[C:10]([C:12]1[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=1)=[O:11]

Participants

3

Reactant 1

HCID 574213535-[2-(2,4-Dichloro-phenyl)-acryloyl]-1H-pyridin-2-one

Product 1

HCID 574213545-[2-(2,4-Dichloro-phenyl)-propionyl]-1H-pyridin-2-oneYield 27.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-[2-(2,4-Dichloro-phenyl)-acryloyl]-1H-pyridin-2-one (840 mg) was hydrogenated in EtOAc using 5% Pd/Alox as a catalyst to give the title compound (233 mg) as a light brown solid. MS (m/e, ISP neg. ion)=293.8 [M−H+].

Sources & evidence

ORD record
ord-b1716aea16d94468a5332855d54d1a14
Source dataset
uspto-grants-2012_03
Patent number
US08143280B2

Reaction notes

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