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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1098087Generated: October 31, 2026

Diethyl Malonate → HCID 57438629, compound

https://huagongshe.com/reaction/1098087

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl MalonateHCID 7761—
Reactant2-Amino-4-methylthiazoleHCID 74143—
Reactant2-Bromoethyl methyl etherHCID 80972—
ProductHCID 57438629HCID 57438629—

Reaction Steps

The title compound was prepared in a manner similar to that described for Intermediate A16 and Intermediate A2 (Step 2-Step 3) starting from diethyl malonate, 2-bromoethyl methyl ether and 2-amino-4-methylthiazol, 1H NMR (300 MHz, CDCl3) δ 10.07 (br s, 1H), 6.53 (d, 1H), 4.68 (br s, 1H), 4.48 (dd, 1H), 3.68 (m, 2H), 3.37 (s, 3H), 2.33 (s, 3H), 2.20 (m, 1H), 2.14 (m, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08143263B2
Source datasetuspto-grants-2012_03
ORD IDord-ec4c2482927a4690b8364424fa2edd5b
Source noteuspto-grants-2012_03