Diethyl Malonate → HCID 57438629, compound

HRID 1098087Notes

Reaction equation

HRID 1098087 reaction equation
[C:1]([O:9][CH2:10]C)(=O)[CH2:2][C:3]([O:5]CC)=O.[CH3:12][O:13]CCBr.[NH2:17][C:18]1[S:19][CH:20]=[C:21]([CH3:23])[N:22]=1>>[OH:5][CH:3]([CH2:2][CH2:1][O:9][CH3:10])[C:12]([NH:17][C:18]1[S:19][CH:20]=[C:21]([CH3:23])[N:22]=1)=[O:13]

Participants

4

Reactant 3

HCID 7761Diethyl MalonateHCID 741432-Amino-4-methylthiazoleHCID 809722-Bromoethyl methyl ether

Product 1

HCID 57438629HCID 57438629, compound

Procedure

The title compound was prepared in a manner similar to that described for Intermediate A16 and Intermediate A2 (Step 2-Step 3) starting from diethyl malonate, 2-bromoethyl methyl ether and 2-amino-4-methylthiazol, 1H NMR (300 MHz, CDCl3) δ 10.07 (br s, 1H), 6.53 (d, 1H), 4.68 (br s, 1H), 4.48 (dd, 1H), 3.68 (m, 2H), 3.37 (s, 3H), 2.33 (s, 3H), 2.20 (m, 1H), 2.14 (m, 1H).

Sources & evidence

ORD record
ord-ec4c2482927a4690b8364424fa2edd5b
Source dataset
uspto-grants-2012_03
Patent number
US08143263B2

Reaction notes

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