Magnesium perchlorate → HCID 59279561, compound

HRID 1098155Notes

Reaction equation

HRID 1098155 reaction equation
Cl([O-])(=O)(=O)=O.[Mg+2].Cl([O-])(=O)(=O)=[O:8].[O:12]1[CH2:14][C@H:13]1[C:15]([O:17][CH3:18])=[O:16].[CH3:19][O:20][CH2:21][C@H:22](O)[CH3:23]>C(OCC)(=O)C>[OH:8][C@@H:13]([CH2:14][O:12][C@H:22]([CH3:23])[CH2:21][O:20][CH3:19])[C:15]([O:17][CH3:18])=[O:16]

Participants

5

Reactant 3

HCID 24840Magnesium perchlorateHCID 2733589(R)-(-)-1-Methoxy-2-propanolHCID 10942355Methyl (2S)-2-oxiranecarboxylate

Product 1

HCID 59279561HCID 59279561, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
50 °C

Procedure

Magnesium perchlorate (2.73 g, 12.24 mmol) was added in one portion to (S)-methyl oxirane-2-carboxylate (CAS no. 118712-39-3) (5 g, 48.98 mmol) and (R)-1-methoxypropan-2-ol (CAS no. 4984-22-9) (4.41 g, 48.98 mmol) at room temperature. The resulting suspension was stirred at 50° C. for 16 hours. The reaction mixture was diluted with ethyl acetate (50 mL) and washed with water (20 mL), dried (MgSO4) and evaporated. This was not isolated and used crude in next step.

Workup

  1. customat room temperature
  2. washwashed with water (20 mL)
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. customThis was not isolated

Sources & evidence

ORD record
ord-c35a9020a5bf4cfb87dd7ca296782420
Source dataset
uspto-grants-2012_03
Patent number
US08143263B2

Reaction notes

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