Phosphorus oxychloride → 3-chloro-2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)benzonitrile

HRID 1098193Notes

Reaction equation

P(Cl)(Cl)([Cl:3])=O.[Cl:6][C:7]1[C:8]([N:15]2[C:19]3=[N:20][CH:21]=[N:22][C:23](O)=[C:18]3[CH:17]=[N:16]2)=[C:9]([CH:12]=[CH:13][CH:14]=1)[C:10]#[N:11]>>[Cl:6][C:7]1[C:8]([N:15]2[C:19]3=[N:20][CH:21]=[N:22][C:23]([Cl:3])=[C:18]3[CH:17]=[N:16]2)=[C:9]([CH:12]=[CH:13][CH:14]=1)[C:10]#[N:11]

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 178509758HCID 178509758, compound

Product 1

HCID 575045663-chloro-2-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)benzonitrile

Procedure

Phosphorus oxychloride (7.93 mL, 85.03 mmol) was added to 3-chloro-2-(4-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-1-yl)benzonitrile (Intermediate AH5) (1.155 g, 4.25 mmol).

Sources & evidence

ORD record: ord-b6d58fadf4354859b685e6a2225472ac
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08143263B2

Reaction notes

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