Azetidine → HCID 66813606, compound
Reaction equation
[O:1]1[CH2:3][C@H:2]1[C:4]([O:6][CH3:7])=[O:5].[NH:8]1[CH2:11][CH2:10][CH2:9]1>C(#N)C>[N:8]1([CH2:3][C@H:2]([OH:1])[C:4]([O:6][CH3:7])=[O:5])[CH2:11][CH2:10][CH2:9]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
(S)-Methyl oxirane-2-carboxylate (1475 mg, 14.45 mmol) in acetonitrile (2 mL)was added to azetidine (825 mg, 14.45 mmol) in acetonitrile (8 mL). The reaction was heated to 100° C. for 60 minutes in the microwave reactor and cooled to room temperature. The mixture was evaporated to afford the crude product (2.3 g) which was used without further purification.
Workup
- temperaturecooled to room temperature
- customThe mixture was evaporated
Sources & evidence
- ORD record
- ord-869f6e2f73bf4c8284c1f8ff9f542964
- Source dataset
- uspto-grants-2012_03
- Patent number
- US08143263B2
Reaction notes
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