反应详情

温度

90 °C

A solution of 1-(5-bromo-6-fluoro-1H-indazol-1-yl)ethanone (24C, 5.0 g, 19.5 mmol) was treated with aq HCl (3M soln., 100 mL) and methanol (20 mL) and heated at 90° C. for 3 h, when the reaction turns homogenous. The reaction mixture was cooled to room temperature and basified with aq. NaOH. A colorless solid precipitated out which was filtered and dried to provide 5-bromo-6-fluoro-1H-indazole (24D)

1. customA colorless solid precipitated out which
2. filtrationwas filtered
3. customdried