Dichloromethane → 1-[[4-(Chloromethyl)phenyl]-(4-chlorophenyl)methyl]-3-[(3,5-difluorophenyl)-methylsulfonylmethylidene]azetidine

HRID 109866Notes

Reaction equation

HRID 109866 reaction equation
[CH3:35][S:36](=[O:37])(=[O:38])[Cl:39].[CH3:40][N:41]([CH3:42])[c:43]1[cH:44][cH:45][n:46][cH:47][cH:48]1.[Cl:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([CH:9]([N:10]2[CH2:11][C:12]([OH:14])([CH:15]([S:16](=[O:17])(=[O:18])[CH3:19])[c:20]3[cH:21][c:22]([F:27])[cH:23][c:24]([F:26])[cH:25]3)[CH2:13]2)[c:28]2[cH:29][cH:30][c:31]([Cl:34])[cH:32][cH:33]2)[cH:7][cH:8]1.[Cl:49][CH2:50][Cl:51]>>[Cl:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([CH:9]([N:10]2[CH2:11][C:12](=[C:15]([S:16](=[O:17])(=[O:18])[CH3:19])[c:20]3[cH:21][c:22]([F:27])[cH:23][c:24]([F:26])[cH:25]3)[CH2:13]2)[c:28]2[cH:29][cH:30][c:31]([Cl:34])[cH:32][cH:33]2)[cH:7][cH:8]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 142844-(Dimethylamino)pyridineHCID 31297Methanesulfonyl chlorideHCID 69635722HCID 69635722, compound

Product 1

HCID 186687391-[[4-(Chloromethyl)phenyl]-(4-chlorophenyl)methyl]-3-[(3,5-difluorophenyl)-methylsulfonylmethylidene]azetidine

Sources & evidence

ORD record
ord-174fbfd3b67545a9a3d68c8378fb4762
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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