反应详情

温度

10 °C

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2 (250 g, 77.6%) as a wheat colored powder.

1. distillationExcess concentrated Hydrochloric acid was distilled off in vacuum
2. filtrationfiltered hot
3. filtrationfiltered
4. customdried