反应详情

温度

10 °C

6-(4-acetylaminophenoxy)-hexanoic acid methyl ester 15 (290 g, 1.04 mol), in conc. HCl (7.12 L) was refluxed for 48 hours. Excess conc. HCl was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 16 (150 g, 55.6%) as a brown powder with an m.p between 155-160° C.

1. distillationExcess conc. HCl was distilled off in vacuum
2. filtrationfiltered hot
3. filtrationfiltered
4. customdried