Potassium Carbonate → HCID 59506298, compound

HRID 1098744Notes

Reaction equation

HRID 1098744 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7](F)=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:5]=1)=[O:3].[CH3:15][O:16][CH2:17][CH2:18][NH:19][CH3:20].C(=O)([O-])[O-].[K+].[K+]>CS(C)=O.O>[CH3:15][O:16][CH2:17][CH2:18][N:19]([CH3:20])[C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH3:1])=[CH:5][C:6]=1[C:11]([F:14])([F:13])[F:12]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 300977(2-Methoxyethyl)(methyl)amineHCID 6056784'-Fluoro-3'-(trifluoromethyl)acetophenone

Product 1

HCID 59506298HCID 59506298, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

A solution of 4-fluoro-3-(trifluoromethyl)acetophenone (500 mg, 2.43 mmol), N-(2-methoxyethyl)methylamine (649 mg, 7.28 mmol) and potassium carbonate (335 mg, 2.43 mmol) in DMSO (6 mL) was stirred for 30 min at 150° C. in the microwave. The cooled reaction mixture was diluted with water, extracted with ethyl acetate, dried over sodium sulphate, filtered and the solvent was removed under reduced pressure. Finally 547 mg (yield: 82%) of the title compound was obtained.

Workup

  1. customThe cooled reaction mixture
  2. extractionextracted with ethyl acetate
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-1e27ac2721c5482586b8fd7638e5cfb8
Source dataset
uspto-grants-2012_03
Patent number
US08143242B2

Reaction notes

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