HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 5-iodo-6-methyl-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1-Acetyl-5-iodo-6-methylindazole | HCID 59339735 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-iodo-6-methyl-1H-indazole | HCID 59339696 | 100.8% |
Reaction Steps
1-Acetyl-5-iodo-6-methylindazole (1.5 g, 5.0 mmol) was stirred with ammonia (7 M in methanol, 4 mL) in methano/THF (2/1, 15 mL) for 1 h. The solution was evaporated to give the subtitle compound (1.3 g, 100%) as an off-white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08143290B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-e5f1e91d0e524ac58251a831aedaba9c |
| Source note | uspto-grants-2012_03 |