Ammonia → 5-iodo-6-methyl-1H-indazole

HRID 1098832Notes

Reaction equation

HRID 1098832 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([I:14])=[C:10]([CH3:13])[CH:11]=2)[CH:6]=[N:5]1)(=O)C.N>C1COCC1>[I:14][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][C:10]=1[CH3:13])[NH:4][N:5]=[CH:6]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 593397351-Acetyl-5-iodo-6-methylindazole

Product 1

HCID 593396965-iodo-6-methyl-1H-indazoleYield 100.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-Acetyl-5-iodo-6-methylindazole (1.5 g, 5.0 mmol) was stirred with ammonia (7 M in methanol, 4 mL) in methano/THF (2/1, 15 mL) for 1 h. The solution was evaporated to give the subtitle compound (1.3 g, 100%) as an off-white powder.

Workup

  1. customThe solution was evaporated

Sources & evidence

ORD record
ord-e5f1e91d0e524ac58251a831aedaba9c
Source dataset
uspto-grants-2012_03
Patent number
US08143290B2

Reaction notes

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