(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate → (S)-tert-butyl 3-oxo-4-phenylbutan-2-ylcarbamate

HRID 1098843Notes

Reaction equation

HRID 1098843 reaction equation
CON(C)[C:4](=[O:15])[C@@H:5]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH3:6].[CH2:17]([Mg]Cl)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[O:15]=[C:4]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C@@H:5]([NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH3:6]

Participants

3

Reactant 2

HCID 11806530(S)-tert-Butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamateHCID 178418336HCID 178418336, compound

Product 1

HCID 59634589(S)-tert-butyl 3-oxo-4-phenylbutan-2-ylcarbamate

Procedure

Prepared as described in Example 6 from (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate (600 mg, 2.58 mmol) and benzylmagnesium chloride (2.0 M in THF, 3.87 mL, 7.75 mmol). Yield 653 mg (96%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bbfe277c401f4fe098a11a270f2bc182
Source dataset
uspto-grants-2012_03
Patent number
US08143290B2

Reaction notes

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