反应详情

To a stirred solution of (1R,2S)-1-(1-(4-fluorophenyl)-1H-indazol-5-yloxy)-1-phenylpentan-2-amine (91a, 13 mg, 0.03 mmol) in dry THF (1 ml) were added, at r.t., triethyl amine (28 μl, 0.2 mmol) and 2-chloro-2-oxoethyl acetate (10.8 μl, 0.1 mmol). The reaction was stirred over night. The solvent was removed under reduced pressure. To the crude solid was added Methanol (300 μl) and ammonium hydroxide (100 μl, 28%). The solution was stirred over night.

1. customThe solvent was removed under reduced pressure
2. additionTo the crude solid was added Methanol (300 μl) and ammonium hydroxide (100 μl, 28%)
3. stirringThe solution was stirred over night