反应详情

(2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol hydrochloride (1.6 g, 6.46 mmol) is stirred overnight in a mixture of 1N NaOH (12.92 mL) and ethyl acetate (20 mL). The organic phase is separated and the aqueous phase is washed twice with ethyl acetate. The combined organic extracts are washed with brine, dried over Na2SO4 and the solvent is evaporated. After purification of the residue by chromatography (silicagel, eluents: dichloromethane/methanol) 694 mg (50.9%) of the title compound as mixture of stereoisomers is obtained.

1. customThe organic phase is separated
2. washthe aqueous phase is washed twice with ethyl acetate
3. washThe combined organic extracts are washed with brine
4. dry with materialdried over Na2SO4
5. customthe solvent is evaporated
6. customAfter purification of the residue by chromatography (silicagel, eluents: dichloromethane/methanol) 694 mg (50.9%) of the title compound
7. additionas mixture of stereoisomers
8. customis obtained