(2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol hydrochloride → (2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol

HRID 1098890노트

반응식

HRID 1098890 반응식
Cl.[NH2:2][C@@H:3]([CH2:13][CH:14]([CH3:16])[CH3:15])[CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[OH:5]>[OH-].[Na+].C(OCC)(=O)C>[NH2:2][C@@H:3]([CH2:13][CH:14]([CH3:16])[CH3:15])[CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[OH:5]

참가 물질

4

반응물 1

HCID 66812770(2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol hydrochloride

생성물 1

HCID 66812540(2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 14798Sodium Hydroxide용매

실험 절차

(2S)-2-Amino-1-(3-fluorophenyl)-4-methyl-pentane-1-ol hydrochloride (1.6 g, 6.46 mmol) is stirred overnight in a mixture of 1N NaOH (12.92 mL) and ethyl acetate (20 mL). The organic phase is separated and the aqueous phase is washed twice with ethyl acetate. The combined organic extracts are washed with brine, dried over Na2SO4 and the solvent is evaporated. After purification of the residue by chromatography (silicagel, eluents: dichloromethane/methanol) 694 mg (50.9%) of the title compound as mixture of stereoisomers is obtained.

후처리

  1. customThe organic phase is separated
  2. washthe aqueous phase is washed twice with ethyl acetate
  3. washThe combined organic extracts are washed with brine
  4. dry with materialdried over Na2SO4
  5. customthe solvent is evaporated
  6. customAfter purification of the residue by chromatography (silicagel, eluents: dichloromethane/methanol) 694 mg (50.9%) of the title compound
  7. additionas mixture of stereoisomers
  8. customis obtained

출처 및 근거

ORD 기록
ord-cb8498f966be471b8dffebac2a066942
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143290B2

반응 노트

불러오는 중…