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HRID1098994

反应详情

EQUATION

反应方程式

HRID 1098994 的结构方程式

REACTANTS

反应物

1
结构：COc1cc([C@@H](O)C(C)NC(=O)OC(C)(C)C)ccc1SC
HCID86623011

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc([C@@H](O)[C@@H](C)N)ccc1SC
HCID66812852

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

t-Butyl (R)-1-hydroxy-1-(3-methoxy-4-(methylthio)phenyl)propan-2-ylcarbamate (308c, 44 μg, 130 μmol) was dissolved in a solution of HC in ethyl acetate (1M, 5 mL) and stirred at 60° C. for 2 h. The solvent was evaporated, and the diastereomers were separated by HPLC (XBridge column). The subtitle compound is the first eluted product, 17 mg (55%).

WORKUP

后处理

  1. customThe solvent was evaporated
  2. customthe diastereomers were separated by HPLC (XBridge column)