Hydrazine → 3-Hydrazinyl-6-phenyl-1,2,4-triazin-5(2H)-one

HRID 1099037Notes

Reaction equation

HRID 1099037 reaction equation
CS[C:3]1[NH:8][C:7](=[O:9])[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:5][N:4]=1.[NH2:16][NH2:17]>C(O)(C)C>[NH:16]([C:3]1[NH:8][C:7](=[O:9])[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:5][N:4]=1)[NH2:17]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 1354506073-(Methylsulfanyl)-6-phenyl-1,2,4-triazin-5(2H)-one

Product 1

HCID 1356045943-Hydrazinyl-6-phenyl-1,2,4-triazin-5(2H)-one

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To 3-(methylthio)-6-phenyl-1,2,4-triazin-5(4H)-one (4.3 g) in isopropyl alcohol (40 mL) was added hydrazine (6.41 g, 0.200 mol). The reaction mixture was refluxed for 10 h. After cooling, the crystalline solid formed was filtered and washed with isopropyl alcohol. The crystalline solid was collected and dried in vacuo to afford the desired product. Analytical LCMS: (M+H)+=204.1.

Workup

  1. temperatureThe reaction mixture was refluxed for 10 h
  2. temperatureAfter cooling
  3. customthe crystalline solid formed
  4. filtrationwas filtered
  5. washwashed with isopropyl alcohol
  6. customThe crystalline solid was collected
  7. customdried in vacuo

Sources & evidence

ORD record
ord-914d415f23ef45d9824884658c56c904
Source dataset
uspto-grants-2012_03
Patent number
US08143251B2

Reaction notes

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