反应详情

To a solution of 4-acetylbenzoic acid methyl ester (25 g, 0.14 mol) in dimethyl sulfoxide (300 mL) was added slowly a solution of hydrogen bromide in water (48%, 48 mL) at RT with stirring. The mixture was stirred at 60° C. overnight. After cooling it was poured into ice-water. The formed precipitate was collected by filtration and dried in-vacuo to afford the desired product (15.6 g, 79%).

1. stirringThe mixture was stirred at 60° C. overnight
2. temperatureAfter cooling it
3. filtrationThe formed precipitate was collected by filtration
4. customdried in-vacuo