反应详情

A mixture of methyl 2-fluoro-4-(oxoacetyl)benzoate (1.60 g), ethyl orthoformate (5.2 mL), p-toluenesulfonic acid monohydrate (70 mg) in toluene (20 mL) was heated under reflux for 3 h. After cooling, the mixture was concentrated. The residue was flash chromatographed on a silica gel column to give the desired product (0.63 g).

1. temperaturewas heated
2. temperatureunder reflux for 3 h
3. temperatureAfter cooling
4. concentrationthe mixture was concentrated
5. customchromatographed on a silica gel column