Trifluoroacetic acid → N-methyl-N-pyridin-2-ylethane-1,2-diamine trifluoroacetate

HRID 1099095Notes

Reaction equation

HRID 1099095 reaction equation
[CH3:1][N:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[CH2:3][CH2:4][NH:5]C(=O)OC(C)(C)C.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]>C(Cl)Cl>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[CH3:1][N:2]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[CH2:3][CH2:4][NH2:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59216311Tert-butyl 2-[methyl(pyridin-2-yl)amino]ethylcarbamate

Product 1

HCID 66813129N-methyl-N-pyridin-2-ylethane-1,2-diamine trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 2-[methyl(pyridin-2-yl)amino]ethylcarbamate was stirred with DCM (0.5 ml) and TFA (0.5 ml) for 30 min. The volatiles were removed under reduced pressure to yield the product.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customto yield the product

Sources & evidence

ORD record
ord-52de3c6fcd584812be89fb6f1cf1a148
Source dataset
uspto-grants-2012_03
Patent number
US08143251B2

Reaction notes

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