Ethanesulfonyl chloride → HCID 49773318, compound

HRID 1099108Notes

Reaction equation

NC1N=C(OCC)C2N=C(C3C=C(NS(C(C)C)(=O)=O)C=CC=3)C=CC=2N=1.[CH2:28]([S:30](Cl)(=[O:32])=[O:31])[CH3:29].[NH2:34][C:35]1[CH:40]=[CH:39][C:38]([C:41]2[CH:42]=[CH:43][C:44]3[N:45]=[C:46]([NH2:54])[N:47]=[C:48]([O:51][CH2:52][CH3:53])[C:49]=3[N:50]=2)=[CH:37][CH:36]=1>>[NH2:54][C:46]1[N:47]=[C:48]([O:51][CH2:52][CH3:53])[C:49]2[N:50]=[C:41]([C:38]3[CH:37]=[CH:36][C:35]([NH:34][S:30]([CH2:28][CH3:29])(=[O:32])=[O:31])=[CH:40][CH:39]=3)[CH:42]=[CH:43][C:44]=2[N:45]=1

Participants

Reactant 3

HCID 11667Ethanesulfonyl chloride

HCID 24959620HCID 24959620, compound

HCID 580198026-(4-Aminophenyl)-4-ethoxypyrido[3,2-d]pyrimidin-2-amine

Product 1

HCID 49773318HCID 49773318, compound

Procedure

Then the procedure of propane-2-sulfonic acid [3-(2-amino-4-ethoxy-pyrido[3,2-d]pyrimidin-6-yl)-phenyl]-amide is repeated, except for the use of ethanesulfonyl chloride instead of isopropylsulfonyl chloride and 6-(4-amino-phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine instead of 6-(3-amino-phenyl)-4-ethoxy-pyrido[3,2-d]pyrimidin-2-ylamine. The resulting product was characterized by its mass spectrum as follows: MS (m/z) 374.0 [M+H]+.

Sources & evidence

ORD record: ord-3725bbf8161042afac44b8f688c06c82
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08143394B2

Reaction notes

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